Effect of Amino Acid Infusion on Central Thermoregulatory Control in Humans

• Yasufumi Nakajima

  Instructor.

• Akira Takamata

  Associate Professor, Department of Environmental Health, Nara Women’s University.

• Takashi Matsukawa

  Associate Professor, Department of Anesthesia, University of Yamanashi, Faculty of Medicine.

• Daniel I. Sessler

  Associate Dean for Research, Director Outcomes Research™ Institute, Lolita & Samuel Weakley Distinguished University Research Chair, Professor of Anesthesiology and Pharmacology, University of Louisville.

• Yoshihiro Kitamura

  Instructor.

• Hiroshi Ueno

  Instructor.

• Yoshifumi Tanaka

  Professor and Chair.

• Toshiki Mizobe

  Associate Professor, Department of Anesthesiology, Kyoto Prefectural University of Medicine.

抄録

Administration of protein or amino acids enhances thermogenesis, presumably by stimulating oxidative metabolism. However, hyperthermia results even when thermoregulatory responses are intact, suggesting that amino acids also alter central thermoregulatory control. Therefore, the authors tested the hypothesis that amino acid infusion increases the thermoregulatory set point. Nine male volunteers each participated on 4 study days in randomized order: (1) intravenous amino acids infused at 4 kJ x kg(-1) x h(-1) for 2.5 h combined with skin-surface warming, (2) amino acid infusion combined with cutaneous cooling, (3) saline infusion combined with skin-surface warming, and (4) saline infusion combined with cutaneous cooling. Amino acid infusion increased resting core temperature by 0.3 +/- 0.1 degrees C (mean +/- SD) and oxygen consumption by 18 +/- 12%. Furthermore, amino acid infusion increased the calculated core temperature threshold (triggering core temperature at a designated mean skin temperature of 34 degrees C) for active cutaneous vasodilation by 0.3 +/- 0.3 degrees C, for sweating by 0.2 +/- 0.2 degrees C, for thermoregulatory vasoconstriction by 0.3 +/- 0.3 degrees C, and for thermogenesis by 0.4 +/- 0.5 degrees C. Amino acid infusion did not alter the incremental response intensity (i.e., gain) of thermoregulatory defenses. Amino acid infusion increased the metabolic rate and the resting core temperature. However, amino acids also produced a synchronous increase in all major autonomic thermoregulatory defense thresholds; the increase in core temperature was identical to the set point increase, even in a cold environment with amble potential to dissipate heat. In subjects with intact thermoregulatory defenses, amino acid-induced hyperthermia seems to result from an increased set point rather than increased metabolic rate per se.

収録刊行物

• Anesthesiology

  Anesthesiology 100 (3), 634-639, 2004-03-01

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Anesthesiology and Pain Medicine

詳細情報

• CRID: 1364233270656378240
• NII論文ID: 30009128972
• DOI: 10.1097/00000542-200403000-00025
• ISSN: 00033022
• ISSN: http://id.crossref.org/issn/00033022
• Web Site: http://pubs.asahq.org/anesthesiology/article-pdf/100/3/634/354695/0000542-200403000-00025.pdf
• Web Site: http://journals.lww.com/00000542-200403000-00025
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  • CiNii Articles