Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat
-
- Sarah A. Loddick
- School of Biological Sciences, University of Manchester, Manchester, England
-
- Nancy J. Rothwell
- School of Biological Sciences, University of Manchester, Manchester, England
抄録
<jats:p> Recombinant human interleukin-1 receptor antagonist (rhIL-1ra) markedly protects against focal cerebral ischaemia in the rat, implicating endogenous IL-1 in the events leading to cerebral infarction. The present experiments investigated the effect of intracerebroventricular (i.c.v.) administration of IL-1β or rhIL-1ra on ischaemia damage and physiological parameters after permanent middle cerebral artery occlusion in the rat. IL-1β (5 ng, i.c.v.) markedly (92%) enhanced infarct volume and caused a significant rise in body temperature, but rhIL-1ra (10 μg, i.c.v.) significantly reduced infarct volume and did not significantly affect heart rate, blood pressure, or body temperature. rhIL-1ra administered 30 min before, or at the time of ischaemia significantly reduced infarct volume in cortex (55 and 60%, respectively) and striatum (52 and 41%, respectively). rhIL-1ra administered 30 min after ischaemia significantly reduced total and cortical infarct volume (26 and 29%, respectively), but did not significantly protect striatal tissue. The effects of rhIL-1ra were still evident in both cortex and striatum 7 days after ischaemia. These results support the role of IL-1 in ischaemic brain damage, revealing potent, sustained, neuroprotective effects of rhIL-1ra in the cortex and striatum, which cannot be attributed directly to changes in physiological parameters. </jats:p>
収録刊行物
-
- Journal of Cerebral Blood Flow & Metabolism
-
Journal of Cerebral Blood Flow & Metabolism 16 (5), 932-940, 1996-09
SAGE Publications
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1360574096370165376
-
- NII論文ID
- 30009334883
-
- ISSN
- 15597016
- 0271678X
- http://id.crossref.org/issn/0271678X
-
- データソース種別
-
- Crossref
- CiNii Articles