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- Benjamin Aspey
- Reta Lila Weston Institute of Neurological Studies, University College London Medical School, Riding House Street, London, England
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- Michael Harrison
- Reta Lila Weston Institute of Neurological Studies, University College London Medical School, Riding House Street, London, England
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<jats:p>We have characterized the induction of the mitogen-inducible form of cyclo-oxygenase, COX-2, during focal cerebral ischemia following permanent middle cerebral artery occlusion (MCAO) in the rat. Marked unilateral induction of COX-2 mRNA was detected in ischemic regions ipsilateral to the occlusion. A significant increase in COX-2 mRNA was detected in “core” and “penumbra” regions of the cerebral cortex between 4 and 24 h after occlusion; this was most marked at 4 h in the penumbra region, in which a 19-fold increase above untreated control levels was detected. A smaller but significant induction was also detected at 4 h in the caudate. A correlation was demonstrated between the extent of COX-2 mRNA induction in cortical regions at 4 h and the severity of tissue damage subsequently detected at 24 h post MCAO. MK-801 significantly attenuated the induction of COX-2 mRNA in the penumbra region at 4 h. The demonstration of COX-2 induction following experimental ischemia highlights the importance of this reaction and its products and by-products, for example, free radicals, in the tissue response to this insult.</jats:p>
収録刊行物
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- Journal of Cerebral Blood Flow & Metabolism
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Journal of Cerebral Blood Flow & Metabolism 16 (6), 1366-1372, 1996-11
SAGE Publications
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詳細情報 詳細情報について
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- CRID
- 1361137045679967360
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- NII論文ID
- 30009334927
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- NII書誌ID
- AA10458430
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- ISSN
- 15597016
- 0271678X
- http://id.crossref.org/issn/0271678X
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