A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice
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- Hugo H. Marti
- Max-Planck UMR6S51-CNRS, Institut, für physiologische und klinische Forschung, Bad Nauheim, Germany
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<jats:p> The present study describes, for the first time, a temporal and spatial cellular expression of erythropoietin (Epo) and Epo receptor (Epo-R) with the evolution of a cerebral infarct after focal permanent ischemia in mice. In addition to a basal expression of Epo in neurons and astrocytes, a postischemic Epo expression has been localized specifically to endothelial cells (1 day), microglia/macrophage-like cells (3 days), and reactive astrocytes (7 days after occlusion). Under these conditions, the Epo-R expression always precedes that of Epo for each cell type. These results support the hypothesis that there is a continuous formation of Epo, with its corresponding receptor, during the active evolution of a focal cerebral infarct and that the Epo/Epo-R system might be implicated in the processes of neuroprotection and restructuring (such as angiogenesis and gliosis) after ischemia. To support this hypothesis, a significant reduction in infarct volume (47%; P < 0.0002) was found in mice treated with recombinant Epo 24 hours before induction of cerebral ischemia. Based on the above, we propose that the Epo/Epo-R system is an endogenous mechanism that protects the brain against damages consequent to a reduction in blood flow, a mechanism that can be amplified by the intracerebroventricular application of exogenous recombinant Epo. </jats:p>
収録刊行物
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- Journal of Cerebral Blood Flow & Metabolism
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Journal of Cerebral Blood Flow & Metabolism 19 (6), 643-651, 1999-06
SAGE Publications
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詳細情報 詳細情報について
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- CRID
- 1363670318382582912
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- NII論文ID
- 30009335286
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- NII書誌ID
- AA10458430
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- ISSN
- 15597016
- 0271678X
- http://id.crossref.org/issn/0271678X
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