Quantitative Comparison of the Bolus and Steady-State Methods for Measurement of Cerebral Perfusion and Oxygen Metabolism: Positron Emission Tomography Study Using <sup>15</sup>O-Gas and Water

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Abstract

<jats:p> To evaluate a new simplified bolus method for measurement of cerebral perfusion and metabolism, the parametric images with that method were compared with those obtained from the conventional steady-state method with <jats:sup>15</jats:sup>O-gas. The new method also provided images of arterial blood volume (V<jats:sub>0</jats:sub>), which is a different parameter from cerebral blood volume (CBV) obtained using a C<jats:sup>15</jats:sup>O technique. Seven healthy volunteers and 10 patients with occlusive cerebrovascular diseases underwent positron emission tomography (PET) scans with both methods. Three-weighted integration was applied to calculate regional cerebral blood flow (rCBF) and regional cerebral metabolic rate of oxygen (rCMRO<jats:sub>2</jats:sub>) in the bolus method. Global and regional CBF and CMRO<jats:sub>2</jats:sub> in volunteers were compared between the two methods and used as control data. Regional values in patients also were evaluated to observe differences between the bilateral hemispheres. Both rCBF and rCMRO<jats:sub>2</jats:sub> were linearly well correlated between the two methods, although global difference in CMRO<jats:sub>2</jats:sub> was significant. The difference in each parametric image except for V<jats:sub>0</jats:sub> was significant between the bilateral hemispheres in patients. The bolus method can simplify oxygen metabolism studies and yield parametric images comparable with those with the steady-state method, and can allow for evaluation of V<jats:sub>0</jats:sub> simultaneously. Increase in CBV without a change in V<jats:sub>0</jats:sub> suggested the increase might mainly be caused by venous dilatation in the ischemic regions. </jats:p>

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