Host-Dependent Tumorigenesis of Embryonic Stem Cell Transplantation in Experimental Stroke

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  • Franciska Erdö
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research
  • Christian Bührle
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research
  • James Blunk
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research
  • Mathias Hoehn
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research
  • Ying Xia
    Institute of Neurophysiology, University of Cologne, Cologne, Germany
  • Bernd Fleischmann
    Institute of Neurophysiology, University of Cologne, Cologne, Germany
  • Melanie Föcking
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research
  • Ekkehardt Küstermann
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research
  • Eugen Kolossov
    Institute of Neurophysiology, University of Cologne, Cologne, Germany
  • Jürgen Hescheler
    Institute of Neurophysiology, University of Cologne, Cologne, Germany
  • Konstantin-A. Hossmann
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research
  • Thorsten Trapp
    Department of Experimental Neurology, Max-Planck Institute for Neurological Research

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<jats:p> The therapeutical potential of transplantation of undifferentiated and predifferentiated murine embryonic stem cells for the regeneration of the injured brain was investigated in two rodent stroke models. Undifferentiated embryonic stem cells xenotransplanted into the rat brain at the hemisphere opposite to the ischemic injury migrated along the corpus callosum towards the damaged tissue and differentiated into neurons in the border zone of the lesion. In the homologous mouse brain, the same murine embryonic stem cells did not migrate, but produced highly malignant teratocarcinomas at the site of implantation, independent of whether they were predifferentiated in vitro to neural progenitor cells. The authors demonstrated a hitherto unrecognized inverse outcome after xenotransplantation and homologous transplantation of embryonic stem cells, which raises concerns about safety provisions when the therapeutical potential of human embryonic stem cells is tested in preclinical animal models. </jats:p>

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