Linearized Reference Tissue Parametric Imaging Methods: Application to [<sup>11</sup>C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain

DOI Web Site Web Site 被引用文献22件
  • Masanori Ichise
    Molecular Imaging Branch, National Institute of Mental Health, Chiba, Japan
  • Jeih-San Liow
    Molecular Imaging Branch, National Institute of Mental Health, Chiba, Japan
  • Jian-Qiang Lu
    Molecular Imaging Branch, National Institute of Mental Health, Chiba, Japan
  • Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
  • Kendra Model
    Molecular Imaging Branch, National Institute of Mental Health, Chiba, Japan
  • Hiroshi Toyama
    Molecular Imaging Branch, National Institute of Mental Health, Chiba, Japan
  • Tetsuya Suhara
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
  • Kazutoshi Suzuki
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
  • Robert B. Innis
    Molecular Imaging Branch, National Institute of Mental Health, Chiba, Japan
  • Richard E. Carson
    PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, U.S.A.

抄録

<jats:p> The authors developed and applied two new linearized reference tissue models for parametric images of binding potential ( BP) and relative delivery ( R<jats:sub>1</jats:sub>) for [<jats:sup>11</jats:sup>C]DASB positron emission tomography imaging of serotonin transporters in human brain. The original multilinear reference tissue model (MRTM<jats:sub>O</jats:sub>) was modified (MRTM) and used to estimate a clearance rate ( k′<jats:sub>2</jats:sub>) from the cerebellum (reference). Then, the number of parameters was reduced from three (MRTM) to two (MRTM2) by fixing k′<jats:sub>2</jats:sub>. The resulting BP and R<jats:sub>1</jats:sub> estimates were compared with the corresponding nonlinear reference tissue models, SRTM and SRTM2, and one-tissue kinetic analysis (1TKA), for simulated and actual [<jats:sup>11</jats:sup>C]DASB data. MRTM gave k′<jats:sub>2</jats:sub> estimates with little bias (<1%) and small variability (<6%). MRTM2 was effectively identical to SRTM2 and 1TKA, reducing BP bias markedly over MRTM<jats:sub>O</jats:sub> from 12–70% to 1–4% at the expense of somewhat increased variability. MRTM2 substantially reduced BP variability by a factor of two or three over MRTM or SRTM. MRTM2, SRTM2, and 1TKA had R<jats:sub>1</jats:sub> bias <0.3% and variability at least a factor of two lower than MRTM or SRTM. MRTM2 allowed rapid generation of parametric images with the noise reductions consistent with the simulations. Rapid parametric imaging by MRTM2 should be a useful method for human [<jats:sup>11</jats:sup>C]DASB positron emission tomography studies. </jats:p>

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