The genetic polymorphism of drug transporters: functional analysis approaches

DOI Web Site 被引用文献11件
  • Toshihisa Ishikawa
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8501, Japan. tishikaw@bio.titech.ac.jp
  • Akira Tsuji
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 9200934, Japan
  • Kenichi Inui
    Department of Pharmacy, Kyoto University Hospital, 54 Shogoinkawaramachi, Sakyo-ku, Kyoto 606-8507, Japan
  • Yoshimichi Sai
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 9200934, Japan
  • Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan
  • Morimasa Wada
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 8128582, Japan
  • Hitoshi Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan
  • Yasuhiro Sumino
    Pharma SNP Consortium, the Japan Pharmaceutical Manufacturer’s Association (JPMA), 3-4-1 Nihonbashihoncho, chuo-ku, Tokyo 103-0023, Japan

抄録

<jats:p> Evidence is accumulating to strongly suggest that drug transporters are one of the determining factors governing the pharmacokinetic profile of drugs. To date, a variety of drug transporters have been cloned and classified as solute carriers and ATP-binding cassette transporters. Such drug transporters are expressed in various tissues such as the intestine, brain, liver, and kidney, and play critical roles in the absorption, distribution and excretion of drugs. However, at the present time, information is limited regarding the genetic polymorphism of drug transporters and its impact on their function. In this context, we have undertaken the functional analyses of the polymorphisms identified in drug transporter genes. This article aims to provide an overview on the functional aspects of the non-synonymous polymorphisms of drug transporters and to present standard methods for the evaluation of the effect of polymorphisms on their function. </jats:p>

収録刊行物

  • Pharmacogenomics

    Pharmacogenomics 5 (1), 67-99, 2004-01-01

    Future Medicine Ltd

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