抄録
<jats:p>Synapses between gustatory receptor cells and primary sensory afferent fibers transmit the output signal from taste buds to the CNS. Several transmitter candidates have been proposed for these synapses, including serotonin (5-HT), glutamate, acetylcholine, ATP, peptides, and others, but, to date, none has been unambiguously identified. We used Chinese hamster ovary cells stably expressing 5-HT<jats:sub>2C</jats:sub>receptors as biodetectors to monitor 5-HT release from taste buds. When taste buds were depolarized with KCl or stimulated with bitter, sweet, or sour (acid) tastants, serotonin was released. KCl- and acid-induced 5-HT release, but not release attributable to sweet or bitter stimulation, required Ca<jats:sup>2+</jats:sup>influx. In contrast, 5-HT release evoked by sweet and bitter stimulation seemed to be triggered by intracellular Ca<jats:sup>2+</jats:sup>release. These experiments strongly implicate serotonin as a taste bud neurotransmitter and reveal unexpected transmitter release mechanisms.</jats:p>
収録刊行物
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- The Journal of Neuroscience
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The Journal of Neuroscience 25 (4), 843-847, 2005-01-26
Society for Neuroscience
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詳細情報 詳細情報について
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- CRID
- 1363670319027178752
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- NII論文ID
- 30010124380
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- ISSN
- 15292401
- 02706474
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- データソース種別
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- Crossref
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