Oxidative Stress Correlates with Left Ventricular Volume after Acute Myocardial Infarction.
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- Fujii Hiroyuki
- Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University
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- Shimizu Masami
- Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University
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- Ino Hidekazu
- Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University
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- Yamaguchi Masato
- Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University
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- Terai Hidenobu
- Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University
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- Mabuchi Hiroshi
- Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University
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- Michishita Ichiro
- Department of Internal Medicine, Yokohama Sakae Kyosai Hospital
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- Genda Akira
- Department of Internal Medicine, Yokohama Sakae Kyosai Hospital
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抄録
It has been suggested that oxidative stress may play a role in the pathophysiology of heart failure. However, little is known about the clinical relationship between oxidative stress and left ventricular dilatation after acute myocardial infarction (AMI). We prospectively studied 28 consecutive patients, successfully treated with primary coronary angioplasty, after their first AMI. To evaluate oxidative stress, plasma oxidized low-density LDL levels (U/mL) were measured serially 1 day, 7 days, 14 days, 30 days, and 90 days after the onset of AMI using a specific sandwich enzyme-linked immunosorbent assay. Left ventriculography and coronary angiography were obtained in all patients 3 months after the AMI and infarct-related arteries were all patent. Peak plasma oxidized LDL levels were seen 7 days after AMI (after 1 day: 14.71.5, 7 days: 21.02.8, 14 days: 20.22.8, 30 days: 18.32.5, 90 days: 16.52.3 U/mL). Plasma oxidized LDL levels 7 days after AMI were significantly correlated with left ventricular end-diastolic volume (1157 mL; r=0.54, P=0.0025) and end-systolic volume (585 mL; r=0.49, P=0.008) 3 months after the AMI. Moreover, they were also correlated with end-diastolic volume index (684 mL/m2, r=0.40, P<0.05). However, no correlation was seen between peak plasma oxidized LDL levels and ejection fraction. These findings suggest that oxidative stress may play an important role in the development and progression of left ventricular remodeling after AMI.<br>
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 43 (3), 203-209, 2002
International Heart Journal刊行会
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詳細情報
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- CRID
- 1390282680015063424
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- NII論文ID
- 130000070844
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- NII書誌ID
- AA00690786
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- COI
- 1:STN:280:DC%2BD38vmvVSgtw%3D%3D
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- ISSN
- 1348673X
- 00214868
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- PubMed
- 12227695
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- 使用不可