Gly¹⁶ + Glu²⁷ β₂-adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans

• Ivani C. Trombetta

• Luciana T. Batalha

• Maria U. P. B. Rondon

• Mateus C. Laterza

• Eliana Frazzatto

• Maria J. N. N. Alves

• Amilton C. Santos

• Patrícia C. Brum

• Antonio C. P. Barretto

• Alfredo Halpern

• Sandra M. F. Villares

• Carlos E. Negrão

抄録

We hypothesized that the muscle vasodilatation during mental stress and exercise would vary among humans who are polymorphic at alleles 16 and 27 of the β 2 -adrenoceptors. From 216 preselected volunteers, we studied 64 healthy, middle-aged normotensive women selected to represent three genotypes: homozygous for the alleles Arg 16 and Gln 27 (Arg 16 /Gln 27 , n = 34), Gly 16 and Gln 27 (Gly 16 /Gln 27 , n = 20), and Gly 16 and Glu 27 (Gly 16 /Glu 27 , n = 10). Forearm blood flow (plethysmography) and muscle sympathetic nerve activity (microneurography) were recorded during 3-min Stroop color-word test and 3-min handgrip isometric exercise (30% maximal voluntary contraction). Baseline muscle sympathetic nerve activity, forearm vascular conductance, mean blood pressure, and heart rate were not different among groups. During mental stress, the peak forearm vascular conductance responses were greater in Gly 16 /Glu 27 group than in Gly 16 /Gln 27 and Arg 16 /Gln 27 groups (1.79 ± 0.66 vs. 0.70 ± 0.11 and 0.58 ± 0.12 units, P = 0.03). Similar results were found during exercise (0.80 ± 0.25 vs. 0.28 ± 0.08 and 0.31 ± 0.08 units, P = 0.02). Further analysis in a subset of subjects showed that brachial intra-arterial propranolol infusion abolished the difference in vasodilatory response between Gly 16 /Glu 27 ( n = 6) and Arg 16 /Gln 27 ( n = 7) groups during mental stress (0.33 ± 0.20 vs. 0.46 ± 0.21 units, P = 0.50) and exercise (0.08 ± 0.06 vs. 0.03 ± 0.03 units, P = 0.21). Plasma epinephrine concentration in Arg 16 /Gln 27 and Gly 16 /Glu 27 groups was similar. In conclusion, women who are homozygous for Gly 16 /Glu 27 of the β 2 -adrenoceptors have augmented muscle vasodilatory responsiveness to mental stress and exercise.

収録刊行物

• Journal of Applied Physiology

  Journal of Applied Physiology 98 (3), 787-794, 2005-03

  American Physiological Society

キーワード

• Physiology (medical)
• Physiology

詳細情報

• CRID: 1360011146459577600
• NII論文ID: 30010380125
• DOI: 10.1152/japplphysiol.00503.2004
• ISSN: 15221601
• ISSN: 87507587
• Web Site: https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00503.2004
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