Expression of <i>tbx20</i> RNA during chick heart development

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<jats:title>Abstract</jats:title><jats:p>The T‐box gene family encodes a set of transcription factors that are involved in various developmental processes. We isolated <jats:italic>tbx20</jats:italic> gene from chick embryos and examined in detail its expression patterns during heart development. In situ hybridization showed that <jats:italic>tbx20</jats:italic> was expressed in the lateral plate mesoderm and subsequently in the primitive heart tube. At stages of looped heart, <jats:italic>tbx20</jats:italic> was localized in the outflow tract (OT) and atrioventricular (AV) canal, in which valvuloseptal endocardial cushion develops. At later stages, although <jats:italic>tbx20</jats:italic> was expressed predominantly in the nascent right ventricle, transcripts of <jats:italic>tbx20</jats:italic> were down‐regulated in the left ventricle. These results suggest that <jats:italic>tbx20</jats:italic> may play important roles in a variety of developmental processes in cardiogenesis, such as chamber‐specification and septation. Developmental Dynamics 230:576–580, 2004. © 2004 Wiley‐Liss, Inc.</jats:p>

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