Mechanical property and biodegradability of solution‐cast films prepared from amphiphilic polylactide‐grafted dextran

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<jats:title>Abstract</jats:title><jats:p>Polylactide (PLA)‐grafted dextran was synthesized with a trimethylsilyl protection method to produce novel biodegradable, biomedical materials. PLA‐grafted dextrans with various lengths and numbers of graft chains were synthesized. The properties of solution‐cast films prepared from PLA‐grafted dextrans were investigated with thermal and dynamic mechanical analyses. The graft‐copolymer films exhibited lower glass‐transition temperatures, melting temperatures (<jats:italic>T</jats:italic><jats:sub>m's</jats:sub>), and crystallinities as well as higher viscosity properties as compared with poly‐<jats:sc>L</jats:sc>‐lactide film. The <jats:italic>T</jats:italic><jats:sub>m</jats:sub> and crystallinity and mechanical properties at 37 °C could be adjusted by controlling the molecular structure such as the lengths and numbers of graft chains. Furthermore, the biodegradability of PLA‐grafted dextran films was investigated through the weight change of film and the molecular weight change of polymer during the <jats:italic>in vitro</jats:italic> degradation test. PLA‐grafted dextrans exhibited different degradation behavior from poly‐<jats:sc>L</jats:sc>‐lactide with the introduction of a polysaccharide segment and branched structure as well as the change of end‐functional group. The degradation rate of PLA‐grafted dextran and the cast film prepared from PLA‐grafted dextran could be adjusted by controlling the sugar content or the length of graft chains. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 2462–2468, 2003</jats:p>

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