Maternal, Neonatal, and Placental Features Associated With Diffuse Chorioamniotic Hemosiderosis, With Special Reference to Neonatal Morbidity and Mortality

DOI PDF 被引用文献14件

抄録

<jats:p>Objective. Our purpose was to examine the significance of diffuse chorioamniotic hemosiderosis (DCH) on neonatal morbidity and mortality.</jats:p> <jats:p>Methods. Using data from a retrospective case-control study, we analyzed 46 singleton placentas with DCH from infants who were delivered and/or admitted to the neonatal intensive care unit of Kanagawa Children’s Medical Center during 1987–2001 and 92 control placentas without DCH from infants of comparable gestational age, birth weight, and duration.</jats:p> <jats:p>Results. Mean and standard deviation of gestational age and infants’ birth weight at delivery from the DCH group were 27 ± 3 weeks and 939 ± 342 g, respectively. Macroscopically, the placentas with DCH were more likely to show old peripheral blood clots (46% in the DCH group vs 8% in control group), subchorionic hematoma (20% vs 1%), and circumvallation (13% vs 1%). Histologically, amniotic necrosis was significantly more frequent in the DCH group (63% vs 24%). Of the obstetric factors, incidence of recurrent episodes of vaginal bleeding (70% vs 11%), oligohydramnios (59% vs 8%), and chronic abruption-oligohydramnios sequence (57% vs 5%) were significantly higher in the DCH group. Of the neonatal factors, persistent pulmonary hypertension of the newborn (29% vs 8%) and dry lung and/or pulmonary hypoplasia (20% vs 4%) were more common. However, respiratory distress syndrome was rare (15% vs 45%) in the DCH group. Neonatal death including stillbirth was increased in the DCH group but was not significant (24% vs 15%). Of infants who survived beyond day 28, chronic lung disease (CLD) was more frequent in the DCH group (51% vs 22%). The association of DCH, especially accompanied by amniotic necrosis, with CLD was still evident using likelihood ratio test.</jats:p> <jats:p>Conclusion. DCH is closely associated with preterm delivery, pulmonary hypertension of the newborn, and dry lung syndrome and is a significant risk factor for CLD.</jats:p>

収録刊行物

  • Pediatrics

    Pediatrics 113 (4), 800-805, 2004-04-01

    American Academy of Pediatrics (AAP)

被引用文献 (14)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ