<i>Bacteroides gingivalis, Bacteroides intermedius</i> and <i>Actinobacillus actinomycetemcomitans</i> in human periodontal diseases

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<jats:p><jats:bold>Abstract</jats:bold> <jats:italic>Bacteroides gingivalis. Bacteroides intermedius</jats:italic> and <jats:italic>Actinobacillus actinomycetemcomitans</jats:italic> seem to be major pathogens in advancing periodontitis in man. First, these organisms are recovered in higher prevalence and proportions from progressive periodontitis lesions than from quiescent periodontal sites. Second, antibody levels against <jats:italic>6. gingivalis</jats:italic> and <jats:italic>A. actinomycetemcomitans</jats:italic> are markedly elevated in serum and gingival crevice fluid of periodontitis patients compared to normal controls. Third. <jats:italic>B. gingivalis</jats:italic> and <jats:italic>B. intermedius</jats:italic> elaborate potent proteases and <jats:italic>A‐ actinomycetemcomitans</jats:italic> various noxious substances which have the potential to perturb important host defenses and to disintegrate key constituents of the periodontal tissues. Monitoring these bacteria in advanced periodontal lesions may greatly assist the assessment of treatment efficacy and risk of further periodontal breakdown.</jats:p>

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