Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

• Shimon Sakaguchi

• Noriko Sakaguchi

• Jun Shimizu

• Sayuri Yamazaki

• Toshiko Sakihama

• Misako Itoh

• Yuhshi Kuniyasu

• Takashi Nomura

• Masaaki Toda

• Takeshi Takahashi

抄録

Summary: There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells contributes to the maintenance of immunologic self‐tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T‐cell population have revealed that CD25 + cells in the CD4 + population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro . The CD25 + CD4 + regulatory T cells, which are naturally anergic and suppressive, appear to be produced by the normal thymus as a functionally distinct subpopulation of T cells. They play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance.

収録刊行物

• Immunological Reviews

  Immunological Reviews 182 (1), 18-32, 2001-08

  Wiley

キーワード

• Immunology
• Immunology and Allergy

詳細情報

• CRID: 1360855571166271744
• NII論文ID: 30013451208
• DOI: 10.1034/j.1600-065x.2001.1820102.x
• ISSN: 1600065X
• ISSN: 01052896
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1600-065X.2001.1820102.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1600-065X.2001.1820102.x
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