Dose-dependent cigarette smoking-related inflammatory responses in healthy adults
抄録
<jats:p>The aim of this study was to determine the dose-response relationship between cigarette smoke exposure and pulmonary cell and cytokine concentrations in bronchoalveolar lavage (BAL). BAL cells and BAL supernatant concentrations of tumour necrosis factor-alpha (TNF alpha), interleukin (IL)-1 beta, IL-6, IL-8, and monocyte chemoattractant protein (MCP)-1 from 14 healthy smokers and 16 healthy nonsmokers were quantified. Statistically greater concentrations of neutrophils, macrophages, IL-1 beta, IL-6, IL-8 and MCP-1 were observed among smokers compared with nonsmokers (p < or = 0.0007 in all cases). Cigarette smoking, categorized ordinally as: less than one pack, one pack, or greater than one pack per day, was predictive of BAL macrophages (p < 0.0001), neutrophils (p = 0.015), IL-1 beta (p < 0.001) and IL-8 (p = 0.02). We conclude that concentrations of macrophages, neutrophils, IL-1 beta and IL-8 are elevated in the pulmonary microenvironment of smokers in a cigarette dose-dependent manner. Based on the present findings, we would caution against simple analyses that treat current smokers as a homogeneous group and which do not account for smoking intensity.</jats:p>
収録刊行物
-
- European Respiratory Journal
-
European Respiratory Journal 9 (10), 1989-1994, 1996-10-01
European Respiratory Society (ERS)
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1360855570424332544
-
- NII論文ID
- 30013492180
-
- ISSN
- 13993003
- 09031936
-
- データソース種別
-
- Crossref
- CiNii Articles