Pathogenic Role of Glutamate in Hyperthermia‐Induced Seizures

• Takehiko Morimoto

• Hideo Nagao

• Makoto Yoshimatsu

• Kazuhiro Yoshida

• Hiroshi Matsuda

抄録

Summary: Hyperthermia induces seizures in both humans and rodents, but the underlying mechanism remains unknown. The present study showed that hyperthermia, causing rapid increase in body temperature, increases the concentration of glutamate (Glu) released into a cortical perfusate before onset of seizures in rats and that this increase in Glu concentration correlated with a decrease in seizure threshold temperature. These results indicate that increased cortical extracellular Glu induced by hyperthermia contributes to onset of seizures. The same mechanism may be involved in clinical seizures induced by fever in patients with febrile convulsions or epilepsy.

収録刊行物

• Epilepsia

  Epilepsia 34 (3), 447-452, 1993-05

  Wiley

キーワード

• Neurology (clinical)
• Neurology

詳細情報

• CRID: 1361418520293178880
• NII論文ID: 30014393044
• NII書誌ID: AA00180597
• DOI: 10.1111/j.1528-1157.1993.tb02585.x
• ISSN: 15281167
• ISSN: 00139580
• ISSN: http://id.crossref.org/issn/00139580
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1157.1993.tb02585.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1157.1993.tb02585.x
• データソース種別:
  • Crossref
  • CiNii Articles