Sequence and analysis of the genetic locus responsible for surfactin synthesis in <i>Bacillus subtilis</i>

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<jats:title>Summary</jats:title><jats:p>The chromosomal region of <jats:italic>Bacillus subtilis</jats:italic> comprising the entire <jats:italic>srfA</jats:italic> operon, <jats:italic>sfp</jats:italic> and about four kilo‐bases in between have been completely sequenced and functionally characterized. The <jats:italic>srfA</jats:italic> gene codes for three large subunits of surfactin synthetase, 402, 401 and 144 kDa, respectively, arranged in a series of seven amino acid activating domains which, as shown in the accompanying communication, recognize and bind the seven amino acids of the surfactin peptide. The <jats:italic>srfA</jats:italic> amino acid activating domains share homologies with similar domains of other peptide synthetases; in particular, regions can be identified which are more homologous in domains activating the same amino acid. A fourth gene in <jats:italic>srfA</jats:italic> encodes a polypeptide homologous to <jats:italic>grsT.</jats:italic> Four genes are positioned between <jats:italic>srfA</jats:italic> and <jats:italic>sfp</jats:italic>, the disruption of which does not affect surfactin biosynthesis.</jats:p>

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