Incidental carcinoma of the prostate: clinicopathological, stereological and immunohistochemical findings studied with logistic regression and self‐organizing feature maps

• T. Mattfeldt

• D. Trijic

• H.‐W. Gottfried

• H.A. Kestler

抄録

To identify significant predictive factors determining category T1a and T1b in incidental prostatic carcinoma with classical and neural multivariate data analysis methods. Incidental prostatic carcinomas diagnosed in our department during 1990–99 (66 cases) were re‐examined. Besides acquiring routine clinical and pathological data the tumours were assessed by scoring immunohistochemistry for proliferative activity and p53‐overexpression. Tumour vascularization (angiogenesis) and epithelial texture variables were investigated by quantitative stereology. The data were evaluated by classical statistical methods ( t ‐test, correlation analysis, logistic regression). Moreover, self‐organizing feature maps (SOMs) were applied as an exploratory approach to unsupervised data analysis by artificial neural networks. The proliferative fraction, p53 overexpression of tumour cell nuclei, preoperative prostate‐specific antigen value and density of capillary vascularization correlated with the Gleason score in incidental prostatic carcinoma. In a stepwise logistic regression analysis with the tumour categories T1a and T1b as dependent variables, the Gleason score and the volume fraction of epithelial cells were significant independent predictors of the tumour category. The cases could be grouped into clusters of different degrees of malignancy using SOMs. Texture variables of tumour cells are of central importance for the extent of propagation in the prostate in incidental prostatic adenocarcinomas. Gleason score and quantitative stereological estimates of the volume fraction of tumour cells are significant predictors of T1a and T1b categories of incidental prostatic carcinoma. Unsupervised clustering of T1 prostate carcinoma cases by SOMs correlates well with the dichotomous classification into T1a and T1b according to the UICC.

収録刊行物

• BJU International

  BJU International 93 (3), 284-290, 2004-02

  Wiley

キーワード

• Urology

詳細情報

• CRID: 1362825893725096192
• NII論文ID: 30014499543
• DOI: 10.1111/j.1464-410x.2004.04603.x
• ISSN: 1464410X
• ISSN: 14644096
• ISSN: http://id.crossref.org/issn/14644096
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1464-410X.2004.04603.x
• Web Site: http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1464-410X.2004.04603.x/fullpdf
• データソース種別:
  • Crossref
  • CiNii Articles