Procalcitonin strip test in the early detection of severe acute pancreatitis

• M-L Kylänpää-Bäck

  Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland

• A Takala

  Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland

• E Kemppainen

  Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland

• P Puolakkainen

  Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland

• R Haapiainen

  Department of Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland

• H Repo

  Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland

抄録

Early identification of patients who subsequently develop severe acute pancreatitis would enable the selection of patients who may benefit from early intensive management. Because severe acute pancreatitis is characterized by the development of systemic inflammation the authors studied whether procalcitonin, a marker of systemic inflammation, differentiated between patients with mild and severe acute pancreatitis. On admission and 24 h thereafter, serum procalcitonin level was measured by a rapid, semiquantitative PCT®-Q test and serum C-reactive protein (CRP) by an immunoturbidimetric method in a consecutive series of 162 patients with acute pancreatitis. There were 38 severe and 124 mild cases. The accuracy of procalcitonin and CRP in predicting severe acute pancreatitis was compared with that of Ranson and Acute Physiology and Chronic Health Evaluation (APACHE) II scores. The PCT®-Q test was more accurate in predicting severe acute pancreatitis (sensitivity 92 per cent and specificity 84 per cent at 24 h) than CRP, APACHE II score and Ranson score. Its negative predictive value was high (97 per cent at 24 h), and it detected each patient who developed subsequent organ failure (n = 22). The PCT®-Q test was a useful screening method for detecting severe acute pancreatitis. It is simple and quick to perform and, unlike currently available multiple factor scoring systems, can easily be adopted into routine clinical practice.

収録刊行物

• British Journal of Surgery

  British Journal of Surgery 88 (2), 222-227, 2001-02

  Oxford University Press (OUP)

キーワード

• Surgery

詳細情報

• CRID: 1361699993505907712
• NII論文ID: 30014602360
• DOI: 10.1046/j.1365-2168.2001.01673.x
• ISSN: 13652168
• ISSN: 00071323
• ISSN: http://id.crossref.org/issn/00071323
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2168.2001.01673.x
• Web Site: http://academic.oup.com/bjs/article-pdf/88/2/222/37841121/bjs397.pdf
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  • CiNii Articles