Genetic instability in patients with metachronous colorectal cancers

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  • S B Sengupta
    Department of Surgery, Universiry College London, London, UK
  • C-Y Yiu
    Department of Surgery, Universiry College London, London, UK
  • P B Boulos
    Department of Surgery, Universiry College London, London, UK
  • M De Silva
    Department of Surgery, Universiry College London, London, UK
  • V R Sams
    Department of Histopatholoa, University College London Medical School, London, UK
  • J D A Delhanty
    Human Genetics Group, Galton Laboratory, Universiry College London, London, UK

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Abstract

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Nearly 7 per cent of patients who undergo resection for colorectal cancer develop metachronous cancers several years later. A molecular marker that could identify patients susceptible to metachronous cancers would be of clinical importance.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Twenty-four colorectal cancers from 15 individuals with metachronous colorectal cancer were investigated for microsatellite instability at five loci by single stranded conformational polymorphism analysis. A control group of 14 colorectal cancers from individuals who had only developed one sporadic colorectal cancer each was analysed similarly.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Microsatellite instability was demonstrated in 17 of 24 cancers from individuals with metachronous cancer compared with one of 14 cancers from individuals with a single colorectal cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>These results suggest that testing for microsatellite instability may be useful in recognizing patients at high risk of developing metachronous colorectal cancers.</jats:p> </jats:sec>

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