Polymorphisms of the <i>ADAM33</i> gene are associated with accelerated lung function decline in asthma

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<jats:title>Summary</jats:title><jats:p><jats:bold>Background </jats:bold> Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper‐responsiveness due to airway inflammation and remodelling. The <jats:italic>ADAM33</jats:italic> gene is associated with asthma and airway hyper‐responsiveness and is postulated as a gene for airway remodelling.</jats:p><jats:p><jats:bold>Objective </jats:bold> To investigate whether polymorphisms of the <jats:italic>ADAM33</jats:italic> gene are associated with accelerated lung function decline in patients with asthma.</jats:p><jats:p><jats:bold>Methods </jats:bold> In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the <jats:italic>ADAM33</jats:italic> gene were analysed to estimate their effect on annual FEV<jats:sub>1</jats:sub> decline.</jats:p><jats:p><jats:bold>Results </jats:bold> The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV<jats:sub>1</jats:sub> (<jats:italic>P</jats:italic><0.05).</jats:p><jats:p><jats:bold>Conclusion </jats:bold> These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.</jats:p>

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