The naive T‐lymphocyte compartment is well preserved in patients with chronic myelogenous leukaemia in chronic phase

• Atsushi Isoda

• Akihiko Yokohama

• Takafumi Matsushima

• Norifumi Tsukamoto

• Yoshihisa Nojima

• Masamitsu Karasawa

抄録

Summary. In chronic myelogenous leukaemia (CML), clonal change occurs in all myeloid and B‐cell lineages, but very rarely T‐cell lineages. A detailed three‐colour cytometric analysis of peripheral lymphocytes was performed in 22 patients with chronic‐phase CML (CP‐CML). CD45 gating analysis was used to discriminate between lymphocytes and basophils. The peripheral lymphocyte pool was comprised of a significant proportion of naive CD4 cells, defined by a CD4 + 45RA + phenotype [47·0 ± 19·6% (mean ± SD) of the total CD4 + cells], and naive CD8 cells, defined by a CD8 + CD45RA + CD28 + phenotype (35·1 ± 19·7% of total CD8 + cells), even in patients with long disease duration. The percentage of CD8 naive T cells showed inverse correlation with age, whereas no correlation was observed with disease duration. Possible explanations for the preservation of naive lymphocytes include (1) that the naive T cells differentiated from co‐existing normal stem cells or (2) that long‐lived naive T cells persisted from the CML onset and expanded peripherally (thymus independent). Either mechanism or a combination of both mechanisms might contribute to maintaining the naive compartment size.

収録刊行物

• British Journal of Haematology

  British Journal of Haematology 119 (4), 949-955, 2002-12

  Wiley

キーワード

• Hematology

詳細情報

• CRID: 1363670319300686848
• NII論文ID: 30014737966
• DOI: 10.1046/j.1365-2141.2002.03943.x
• ISSN: 13652141
• ISSN: 00071048
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2141.2002.03943.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2141.2002.03943.x
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  • CiNii Articles