Curing <i>Helicobacter pylori</i> Infection in Patients with Duodenal Ulcer Does Not Provoke Gastroesophageal Reflux Disease

DOI Web Site Web Site Web Site 被引用文献5件

抄録

<jats:p><jats:bold>Background.</jats:bold> It has been suggested that the incidence of gastroesophageal reflux disease (GERD) increases after successful eradication of <jats:italic>Helicobacter pylori</jats:italic> infection. We present data on development of GERD from a controlled study of <jats:italic>H. pylori</jats:italic> eradication in 165 duodenal ulcer patients.</jats:p><jats:p><jats:bold>Methods.</jats:bold> Patients (mean age, 55 years; 102 men; current smokers; n = 74) were randomly assigned 2 : 1 to receive omeprazole, 40 mg twice daily, in combination with either amoxicillin, 750 mg twice daily, or placebo. Endoscopy and dyspeptic symptoms, including heartburn, were assessed at inclusion and at 6, 12, and 24 months after treatment. In addition, symptoms were assessed at 18 months. Patients with erosive esophagitis or reflux symptoms requiring treatment at inclusion were not included in the study.</jats:p><jats:p><jats:bold>Results.</jats:bold> Fifty‐one of 145 (35%) evaluable patients developed heartburn, and 13 of 145 (9%) developed esophagitis during follow‐up. The life‐table analysis of the cumulated risk of developing heartburn showed that patients whose <jats:italic>H. pylori</jats:italic> infection was eradicated had a significantly lower risk for developing heartburn than those with persistent <jats:italic>H. pylori</jats:italic> infection. The groups did not show any difference in cumulative risk of developing esophagitis.</jats:p><jats:p><jats:bold>Conclusion.</jats:bold> Our data show that successful eradication of <jats:italic>H. pylori</jats:italic> infection does not increase the incidence of GERD in duodenal ulcer patients.</jats:p>

収録刊行物

被引用文献 (5)*注記

もっと見る

キーワード

問題の指摘

ページトップへ