Organ‐Specific Autoantibodies in Children with <i>Helicobacter pylori</i> Infection
抄録
<jats:title>ABSTRACT</jats:title><jats:p><jats:bold>Background. </jats:bold> We compared the prevalence of organ‐specific autoantibodies in a group of <jats:italic>Helicobacter pylori</jats:italic> infected children and a group of uninfected children and investigated the relationship between the presence of relevant autoantibodies and the status of the target organs.</jats:p><jats:p><jats:bold>Patients and Methods. </jats:bold> One hundred and twenty‐four children with dyspepsia (54 boys, 70 girls; mean age 10.5 years; range 4–19) underwent gastroscopy: 56 had <jats:italic>H. pylori</jats:italic> infection (31 girls, 25 boys), while 68 (37 girls and 31 boys), were <jats:italic>H. pylori</jats:italic>‐negative. All sera were tested for the presence of: parietal cell autoantibodies (PCA), intrinsic factor autoantibodies (IFA), microsomial autoantibodies, thyroglobulin autoantibodies, islet cell autoantibodies, glutamic acid decarboxylase autoantibodies, adrenal cortex autoantibodies, steroid‐producing cell autoantibodies; gastrin, pepsinogen A, pepsinogen C and anti‐<jats:italic>H. pylori</jats:italic> antibodies. The histological features and the <jats:italic>ureA</jats:italic> and <jats:italic>cagA</jats:italic> genes were also considered.</jats:p><jats:p><jats:bold>Results. </jats:bold> The frequency of organ‐specific autoantibodies was higher in patients with <jats:italic>H. pylori</jats:italic> infection than in uninfected patients (χ<jats:sup>2</jats:sup>‐test <jats:italic>p</jats:italic> < .0001). Specifically gastric autoantibodies were significantly higher: seven of the 56 <jats:italic>H. pylori</jats:italic>‐positive children were PCA‐positive and one was IFA‐positive (χ<jats:sup>2</jats:sup>‐test <jats:italic>p</jats:italic> = .0004). The presence of autoantibodies was not associated with any clinical or biohumoral signs of disease.</jats:p><jats:p><jats:bold>Conclusions. </jats:bold> Our study detected a relationship between <jats:italic>H. pylori</jats:italic> infection in childhood and the presence of organ‐specific autoantibodies unassociated with any clinical or biohumoral signs of disease. <jats:italic>Helicobacter pylori</jats:italic> infection in childhood could trigger the onset of clinical autoimmune gastritis, and/or other clinical autoimmune diseases.</jats:p>
収録刊行物
-
- Helicobacter
-
Helicobacter 9 (6), 622-628, 2004-12
Wiley
- Tweet
詳細情報
-
- CRID
- 1360292618750568576
-
- NII論文ID
- 30014798420
-
- ISSN
- 15235378
- 10834389
- http://id.crossref.org/issn/10834389
-
- データソース種別
-
- Crossref
- CiNii Articles