Antifungal activity of plant extracts against dermatophytes

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<jats:p>The aqueous extracts (15 μg ml<jats:sup>−1</jats:sup> medium) of 22 plants used in folkloric medicine in Palestine were investigated for their antifungal activity and minimum inhibitory concentrations (MICs) against nine isolates of <jats:italic>Microsporum canis, Trichophyton mentagrophytes</jats:italic> and <jats:italic>Trichophyton violaceum.</jats:italic> The extract of the different plant species reduced colony growth of the three dermatophytes by 36 to 100% compared with the control treatment. Antimycotic activity of the extract against the three dermatophytes varied significantly (<jats:italic>P</jats:italic><0.05) between test plants. Extracts of <jats:italic>Capparis spinosa</jats:italic> and <jats:italic>Juglans regia</jats:italic> completely prevented growth of <jats:italic>M. canis</jats:italic> and <jats:italic>T. violaceum</jats:italic>. The most active extracts (90–100% inhibition) were those of <jats:italic>Anagallis arvensis, C. spinosa, J. regia, Pistacia lentiscus </jats:italic>and <jats:italic>Ruta chalapensis </jats:italic>against<jats:italic> M. canis; Inula viscosa, J. regia </jats:italic>and<jats:italic> P. lentiscus </jats:italic>against<jats:italic> T. mentagrophytes</jats:italic>; and <jats:italic>Asphodelus luteus</jats:italic>, <jats:italic>A. arvensis</jats:italic>, <jats:italic>C. spinosa</jats:italic>, <jats:italic>Clematis cirrhosa</jats:italic>, <jats:italic>I. viscosa</jats:italic>, <jats:italic>J. regia</jats:italic>, <jats:italic>P. lentiscus</jats:italic>, <jats:italic>Plumbago europea</jats:italic>, <jats:italic>Ruscus aculeatus</jats:italic>, <jats:italic>Retema raetam</jats:italic> and <jats:italic>Salvia fruticosa </jats:italic>against<jats:italic> T. violaceum</jats:italic>. The MICs of these most active plants ranged from 0.6 to 40 μg ml<jats:sup>−1</jats:sup>. The three dermatophytes differed significantly with regard to their susceptibility to plant extracts. <jats:italic>Trichophyton violaceum</jats:italic> was the most susceptible being completely inhibited by 50% of the extracts followed by <jats:italic>M. canis</jats:italic> and <jats:italic>T. mentagrophytes</jats:italic> which were completely inhibited by only 23 and 14% of the extracts, respectively.</jats:p>

収録刊行物

  • Mycoses

    Mycoses 42 (11-12), 665-672, 1999-12

    Wiley

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