Pancreatic toxicity after liposomal amphotericin B

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  • Pankreastoxizität nach liposomalem Amphotericin B

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<jats:p><jats:bold>Summary. </jats:bold> Though liposomal amphotericin B has been available in Germany since 1992, efficacy and safety of this formulation of amphotericin B are still not well‐documented in children. As far as gastrointestinal side‐effects are concerned, an elevated alkaline phosphatase and elevated transaminases have been reported. In our department, liposomal amphotericin B had been used since 1994 to treat patients with proven or suspected fungal infections in a daily dose of 1–3 mg kg<jats:sup>−1</jats:sup>. Additionally, patients with high‐dose chemotherapy and autologous stem cell support received liposomal amphotericin B prophylactically in a dose of 1 mg kg<jats:sup>−1</jats:sup> three times per week. We performed a retrospective analysis of all 31 patients who had received liposomal amphotericin B by 1999. In five patients, an isolated transient elevation of the serum lipase level during, or shortly after, the therapy with liposomal amphotericin B was detected. Three of these patients showed clinical signs of pancreatitis, with one patient displaying slightly elevated transaminases. So far, elevated levels of serum lipase have not been described as a possible side‐effect of a liposomal amphotericin B therapy. The pathogenesis of this elevation is unclear. As possible reasons, an enzyme induction due to fat overload or a toxic damage of the pancreatic tissue by the liposomes or amphotericin B itself are discussed.</jats:p>

収録刊行物

  • Mycoses

    Mycoses 45 (5-6), 170-173, 2002-06

    Wiley

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