Renal Compensation for Body Water Loss during Dehydration in Neonatal Rats.
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- ANZAI Naohiko
- Department of Physiology, Kitasato University School of Medicine
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- KAWAHARA Katsumasa
- Department of Physiology, Kitasato University School of Medicine
書誌事項
- タイトル別名
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- Renal Compensation for Body Water Loss
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抄録
The present study was designed to investigate whether the limited capacity for concentrating urine in neonatal rats is associated with an immature ability to regulate serum osmolality. During milk deprivation, the percent of reduction in body weight per 10 h (mean±SE) was 4.3±0.2, 3.7±0.1, 4.8±0.2, and 6.0±0.1% in 4-, 7-, 10-, and 14-d-old rats, respectively (n=23-24, each age). The osmolality of urine increased to 718±12 (4d), 741±28 (7d), 792±20 (10d), and 1, 203±41 mosmol/kg H2O (14d). Free-water absorption (TcH<SUB>2O</SUB>) Promptly increased after deprivation of milk: It significantly increased from 2.3±0.3 (0-4h) to 3.4±0.1 (4-7h) (4d), from 3.1±0.3 to 4.1±0.3 (7d), from 3.6±0.4 to 5.2±0.3 (10d), and from 5.0±0.4 to 7.9±0.7 μl/min/100g (14d). The raised values were maintained at the later period of dehydration. Thus serum osmolality was unchanged throughout dehydration: 287±1.0 (7d) and 292±0.9 mosmol/kg H2O (14d). On the other hand, the level of serum sodium concentration slightly but significantly increased (r=0.61) when the body weight reduction was higher than 5% of the control (14-d-old rats). These results indicate that neonatal rats of 4-14d control their serum osmolality by reabsorbing free water in the kidney during the 10 or 12h of milk deprivation.
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 48 (3), 181-187, 1998
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205043089408
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- NII論文ID
- 130004435665
- 30015529397
- 10008304533
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- NII書誌ID
- AA00691224
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- COI
- 1:STN:280:DyaK1czls1SmtA%3D%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 4528288
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- PubMed
- 9689147
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可