Orexin A activates locus coeruleus cell firing and increases arousal in the rat

DOI Web Site 被引用文献33件
  • Jim J. Hagan
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Ron A. Leslie
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Sara Patel
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Martyn L. Evans
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Trevor A. Wattam
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Steve Holmes
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Christopher D. Benham
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Stephen G. Taylor
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Carol Routledge
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Panida Hemmati
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Richard P. Munton
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Tracey E. Ashmeade
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Ajit S. Shah
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Jonathan P. Hatcher
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Paula D. Hatcher
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Declan N. C. Jones
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Martin I. Smith
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • David C. Piper
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • A. Jackie Hunter
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Rod A. Porter
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW
  • Neil Upton
    Neuroscience Research, Biopharmaceutical Development, Analytical Sciences, and Department of Discovery Chemistry, Europe, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, United Kingdom CM19 5AW

抄録

<jats:p>The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.</jats:p>

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