Heteromultimeric CLC chloride channels with novel properties

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  • Claudius Lorenz
    Center for Molecular Neurobiology, Hamburg University, Martinistrasse 52, D-20246 Hamburg, Germany
  • Michael Pusch
    Center for Molecular Neurobiology, Hamburg University, Martinistrasse 52, D-20246 Hamburg, Germany
  • Thomas J. Jentsch
    Center for Molecular Neurobiology, Hamburg University, Martinistrasse 52, D-20246 Hamburg, Germany

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<jats:p> The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in <jats:italic>Xenopus</jats:italic> oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride → bromide → iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels. </jats:p>

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