Identification of anthrax toxin genes in a<i>Bacillus cereus</i>associated with an illness resembling inhalation anthrax

DOI Web Site 被引用文献5件
  • Alex R. Hoffmaster
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Jacques Ravel
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • David A. Rasko
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Gail D. Chapman
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Michael D. Chute
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Chung K. Marston
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Barun K. De
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Claudio T. Sacchi
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Collette Fitzgerald
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Leonard W. Mayer
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Martin C. J. Maiden
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Fergus G. Priest
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Margaret Barker
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Lingxia Jiang
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Regina Z. Cer
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Jennifer Rilstone
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Scott N. Peterson
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Robbin S. Weyant
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Darrell R. Galloway
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Timothy D. Read
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Tanja Popovic
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...
  • Claire M. Fraser
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333; Microbial Genomics and Pathogen Functional Genomic Resource Center, Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; School of Life Sciences, Heriot Watt...

抄録

<jats:p><jats:italic>Bacillus anthracis</jats:italic>is the etiologic agent of anthrax, an acute fatal disease among mammals. It was thought to differ from<jats:italic>Bacillus cereus</jats:italic>, an opportunistic pathogen and cause of food poisoning, by the presence of plasmids pXO1 and pXO2, which encode the lethal toxin complex and the poly-γ-<jats:sc>d</jats:sc>-glutamic acid capsule, respectively. This work describes a non-<jats:italic>B. anthracis</jats:italic>isolate that possesses the anthrax toxin genes and is capable of causing a severe inhalation anthrax-like illness. Although initial phenotypic and 16S rRNA analysis identified this isolate as<jats:italic>B. cereus</jats:italic>, the rapid generation and analysis of a high-coverage draft genome sequence revealed the presence of a circular plasmid, named pBCXO1, with 99.6% similarity with the<jats:italic>B. anthracis</jats:italic>toxin-encoding plasmid, pXO1. Although homologues of the pXO2 encoded capsule genes were not found, a polysaccharide capsule cluster is encoded on a second, previously unidentified plasmid, pBC218. A/J mice challenged with<jats:italic>B. cereus</jats:italic>G9241 confirmed the virulence of this strain. These findings represent an example of how genomics could rapidly assist public health experts responding not only to clearly identified select agents but also to novel agents with similar pathogenic potentials. In this study, we combined a public health approach with genome analysis to provide insight into the correlation of phenotypic characteristics and their genetic basis.</jats:p>

収録刊行物

被引用文献 (5)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ