Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles

DOI Web Site 被引用文献17件
  • Hiroki R. Ueda
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Limited, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan; Department of Pharmacology, Graduate School of Medicine, University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, 2-2-3 Minatojiima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; and Department of Physiology, Hokkaido University Graduate School of Medicine,...
  • Wenbin Chen
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Limited, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan; Department of Pharmacology, Graduate School of Medicine, University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, 2-2-3 Minatojiima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; and Department of Physiology, Hokkaido University Graduate School of Medicine,...
  • Yoichi Minami
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Limited, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan; Department of Pharmacology, Graduate School of Medicine, University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, 2-2-3 Minatojiima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; and Department of Physiology, Hokkaido University Graduate School of Medicine,...
  • Sato Honma
  • Kenichi Honma
  • Masamitsu Iino
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Limited, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan; Department of Pharmacology, Graduate School of Medicine, University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, 2-2-3 Minatojiima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; and Department of Physiology, Hokkaido University Graduate School of Medicine,...
  • Seiichi Hashimoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Limited, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan; Department of Pharmacology, Graduate School of Medicine, University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, 2-2-3 Minatojiima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; and Department of Physiology, Hokkaido University Graduate School of Medicine,...

抄録

<jats:p>Detection of individual body time (BT) via a single-time-point assay has been a longstanding unfulfilled dream in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To achieve this dream, we created a “molecular timetable” composed of >100 “time-indicating genes,” whose gene expression levels can represent internal BT. Here we describe a robust method called the “molecular-timetable method” for BT detection from a single-time-point expression profile. The power of this method is demonstrated by the sensitive and accurate detection of BT and the sensitive diagnosis of rhythm disorders. These results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine.</jats:p>

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