Structural flexibility in the <i>Burkholderia mallei</i> genome

DOI Web Site 被引用文献4件
  • William C. Nierman
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • David DeShazer
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • H. Stanley Kim
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Herve Tettelin
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Karen E. Nelson
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Tamara Feldblyum
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Ricky L. Ulrich
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Catherine M. Ronning
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Lauren M. Brinkac
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Sean C. Daugherty
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Tanja D. Davidsen
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Robert T. Deboy
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • George Dimitrov
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Robert J. Dodson
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • A. Scott Durkin
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Michelle L. Gwinn
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Daniel H. Haft
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Hoda Khouri
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • James F. Kolonay
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Ramana Madupu
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Yasmin Mohammoud
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • William C. Nelson
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Diana Radune
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Claudia M. Romero
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Saul Sarria
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Jeremy Selengut
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Christine Shamblin
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Steven A. Sullivan
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Owen White
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Yan Yu
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Nikhat Zafar
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Liwei Zhou
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011
  • Claire M. Fraser
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Departments of Biochemistry and Molecular Biology, Pharmacology, and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037; and U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011

抄録

<jats:p> The complete genome sequence of <jats:italic>Burkholderia mallei</jats:italic> ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. <jats:italic>B. mallei</jats:italic> , the etiologic agent of glanders, has come under renewed scientific investigation as a result of recent concerns about its past and potential future use as a biological weapon. Genome analysis identified a number of putative virulence factors whose function was supported by comparative genome hybridization and expression profiling of the bacterium in hamster liver <jats:italic>in vivo</jats:italic> . The genome contains numerous insertion sequence elements that have mediated extensive deletions and rearrangements of the genome relative to <jats:italic>Burkholderia pseudomallei</jats:italic> . The genome also contains a vast number (>12,000) of simple sequence repeats. Variation in simple sequence repeats in key genes can provide a mechanism for generating antigenic variation that may account for the mammalian host's inability to mount a durable adaptive immune response to a <jats:italic>B. mallei</jats:italic> infection. </jats:p>

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