The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells

DOI Web Site 被引用文献3件
  • Emmelie Å. Jansson
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden; Departments of Paediatrics and Biochemistry, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074; and Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
  • Alexandra Are
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden; Departments of Paediatrics and Biochemistry, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074; and Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
  • Gediminas Greicius
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden; Departments of Paediatrics and Biochemistry, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074; and Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
  • I-Chun Kuo
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden; Departments of Paediatrics and Biochemistry, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074; and Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
  • Denise Kelly
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden; Departments of Paediatrics and Biochemistry, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074; and Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
  • Velmurugesan Arulampalam
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden; Departments of Paediatrics and Biochemistry, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074; and Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
  • Sven Pettersson
    Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden; Departments of Paediatrics and Biochemistry, Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074; and Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom

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<jats:p>Control of colon cell fate in adenocarcinomas is disrupted, in part, due to aberrant Wnt/β-catenin signaling. The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) has been implicated in the development of colon cancers. In the adenomatous polyposis coli multiple intestinal neoplasia (APC<jats:sup>Min</jats:sup>) mouse cancer model, PPARγ expression in the colonic mucosa is markedly altered. In addition, PPARγ protein levels are elevated, possibly through sequestration by activated β-catenin in colon cancer cell lines. Induction of the Wnt/β-catenin pathway by LiCl also elevated PPARγ levels and induced PPARγ-dependent reporter and endogenous target genes. Mechanistically, PPARγ, through interactions with β-catenin and T cell transcription factor (Tcf)-4, may be a determinant of cell fate and is likely a target of the Wnt pathway in cancer cells.</jats:p>

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