Slow Joining of Newly Replicated DNA Chains in DNA Polymerase I-Deficient <i>Escherichia coli</i> Mutants

• Reiji Okazaki

  Institute of Molecular Biology, Faculty of Science, Nagoya University, Nagoya, Japan

• Mikio Arisawa

  Institute of Molecular Biology, Faculty of Science, Nagoya University, Nagoya, Japan

• Akio Sugino

  Institute of Molecular Biology, Faculty of Science, Nagoya University, Nagoya, Japan

抄録

In Escherichia coli mutants deficient in DNA polymerase I, newly replicated short DNA is joined at about 10% of the rate in the wild-type strains. It is postulated that DNA polymerase I normally functions in filling gaps between the nascent short segments synthesized by the replication complex. Possible implications of the finding are discussed in relation to other abnormal properties of these mutants.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 68 (12), 2954-2957, 1971-12

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361699993382933376
• NII論文ID: 30016258499
• DOI: 10.1073/pnas.68.12.2954
• ISSN: 10916490
• ISSN: 00278424
• ISSN: http://id.crossref.org/issn/00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.68.12.2954
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