Cholinergic Augmentation of Lymphocyte-Mediated Cytotoxicity. A Study of the Cholinergic Receptor of Cytotoxic T Lymphocytes

• Terry B. Strom

  Harvard Medical School, Peter Bent Brigham Hospital, Immunology Laboratory, Boston, Massachusetts 02115

• Arthur J. Sytkowski

  Harvard Medical School, Peter Bent Brigham Hospital, Department of Medicine, Biophysics Research Laboratory, Boston, Massachusetts 02115

• Charles B. Carpenter

  Harvard Medical School, Peter Bent Brigham Hospital, Immunology Laboratory, Boston, Massachusetts 02115

• John P. Merrill

  Harvard Medical School, Peter Bent Brigham Hospital, Immunology Laboratory, Boston, Massachusetts 02115

抄録

Cholinergic agonists have previously been shown to augment the ability of sensitized lymphocytes to injure cells bearing the sensitizing alleantigens. The cholinergic receptor of the attacking lymphocyte population has been studied with pharmacological manipulation of an in vitro system that quantitates the injury mediated by sensitized attacking cells upon target cells. The data reveal that muscarinic ligands are several orders of magnitude more potent than nicotinic agents in altering cytotoxicity.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 71 (4), 1330-1333, 1974-04

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361418519285866240
• NII論文ID: 30016261430
• DOI: 10.1073/pnas.71.4.1330
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.71.4.1330
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