Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens.

• X Y Fu

  AntiCancer, Inc., San Diego, CA 92110.

• J M Besterman

  AntiCancer, Inc., San Diego, CA 92110.

• A Monosov

  AntiCancer, Inc., San Diego, CA 92110.

• R M Hoffman

  AntiCancer, Inc., San Diego, CA 92110.

抄録

There is an important need for clinically relevant animal models for human cancers. Toward this goal, histologically intact human colon-cancer specimens derived surgically from patients were implanted orthotopically to the colon or cecum of nude mice. We have observed extensive orthotopic growth in 13 of 20 cases of implanted patient colon tumors. These showed various growth patterns with subsequent regional, lymph-node, and liver metastasis, as well as general abdominal carcinomatosis. Thus, models for human colon cancer have been developed that show (i) local growth, (ii) abdominal metastasis, (iii) general abdominal carcinomatosis with extensive peritoneal seeding, (iv) lymph-node metastasis, (v) liver metastasis, and (vi) colonic obstruction. These models permit the passage of the tumors to form large cohorts. They will facilitate research into the biology of colon cancer metastatic capability and the development of new drugs active against metastatic cancer. These models may also predict the clinical course and the in vivo response to drugs of the cancer of individual patients.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 88 (20), 9345-9349, 1991-10-15

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360855570156263680
• NII論文ID: 30016290228
• DOI: 10.1073/pnas.88.20.9345
• ISSN: 10916490
• ISSN: 00278424
• ISSN: http://id.crossref.org/issn/00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.88.20.9345
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