Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.

• R Fässler

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

• P N Schnegelsberg

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

• J Dausman

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

• T Shinya

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

• Y Muragaki

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

• M T McCarthy

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

• B R Olsen

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

• R Jaenisch

  Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

抄録

Type IX collagen is a nonfibrillar collagen composed of three gene products, alpha 1(IX), alpha 2(IX), and alpha 3(IX). Type IX molecules are localized on the surface of type II-containing fibrils and consist of two arms, a long arm that is crosslinked to type II collagen and a short arm that projects into the perifibrillar space. In hyaline cartilage, the alpha 1(IX) collagen transcript encodes a polypeptide with a large N-terminal globular domain (NC4), whereas in many other tissues an alternative transcript encodes an alpha 1(IX) chain with a truncated NC4 domain. It has been proposed that type IX molecules are involved in the interaction of fibrils with each other or with other components of the extracellular matrix. To test this hypothesis, we have generated a mouse strain lacking both isoforms of the alpha 1(IX) chain. Homozygous mutant mice are viable and show no detectable abnormalities at birth but develop a severe degenerative joint disease resembling human osteoarthritis.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 91 (11), 5070-5074, 1994-05-24

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361981469558858368
• NII論文ID: 30016296695
• DOI: 10.1073/pnas.91.11.5070
• ISSN: 10916490
• ISSN: 00278424
• ISSN: http://id.crossref.org/issn/00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.91.11.5070
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