Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis.
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- C Morimoto
- Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.
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- C I Lord
- Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.
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- C Zhang
- Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.
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- J S Duke-Cohan
- Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.
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- N L Letvin
- Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.
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- S F Schlossman
- Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.
抄録
<jats:p>To examine the role of CD26/dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) in infection by human immunodeficiency virus type 1 (HIV-1), we utilized CD26 cDNA-transfected Jurkat T-cell lines. Both CD26- parental Jurkat cells and mutant CD26+ (DPPIV-) transfected Jurkat cells were readily infected with HIV-1, whereas wild-type CD26+ (DPPIV+) transfected Jurkat cells were more resistant to HIV-1 infection. Our results suggest that CD26 is not essential for HIV-1 infectivity as suggested by others but that DPPIV enzyme activity may decrease the efficiency of HIV-1 infection. Of great interest, we found that mutant CD26+ (DPPIV-) transfectants and CD26- parental Jurkat cells strongly expressed CD95 (Fas/Apo-1) and were more sensitive than wild-type CD26+ (DPPIV+) transfectants to the induction of apoptosis by anti-CD95 monoclonal antibody. These results suggest that CD26 may play a role in HIV-1-associated loss of -CD4+ cells through the process of programmed cell death.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 91 (21), 9960-9964, 1994-10-11
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1363951795099741696
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- NII論文ID
- 30016297544
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- ISSN
- 10916490
- 00278424
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