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- Hidehiro Kishimoto
- From the Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037
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- Jonathan Sprent
- From the Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037
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抄録
<jats:p>The thymic medulla plays a key role in negative selection (self-tolerance induction) and contains differentiated T cells en route to the extrathymic environment. However, being relatively mature, medullary T cells are thought to be beyond the stage of tolerance induction. This paradox is resolved by the finding that medullary T cells (CD4+8− thymocytes) comprise two distinct subsets. Medullary thymocytes expressing a fully mature (HSAlo) phenotype are strongly resistant to tolerance induction, whereas cells with a semimature (HSAhi) phenotype are tolerance susceptible. These findings suggest that the differentiated T cells reaching the medulla from the cortex remain sensitive to tolerance induction for a brief period before acquiring a fully mature tolerance-resistant phenotype. The semimature subset of medullary T cells displays unique requirements for tolerance induction; depending upon the conditions used, tolerizing these cells can involve either a Fas (CD95)-dependent or a Fas-independent pathway.</jats:p>
収録刊行物
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- The Journal of Experimental Medicine
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The Journal of Experimental Medicine 185 (2), 263-272, 1997-01-20
Rockefeller University Press
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詳細情報
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- CRID
- 1360576122620046208
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- NII論文ID
- 30017415364
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- NII書誌ID
- AA00697559
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- ISSN
- 15409538
- 00221007
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