Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells
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- Detlef Dieckmann
- Department of Dermatology, University Hospital of Erlangen, 91052 Erlangen, Germany
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- Cord Henrik Bruett
- Department of Dermatology, University Hospital of Erlangen, 91052 Erlangen, Germany
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- Heidi Ploettner
- Department of Dermatology, University Hospital of Erlangen, 91052 Erlangen, Germany
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- Manfred Bernhard Lutz
- Department of Dermatology, University Hospital of Erlangen, 91052 Erlangen, Germany
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- Gerold Schuler
- Department of Dermatology, University Hospital of Erlangen, 91052 Erlangen, Germany
抄録
<jats:p>It has been recently demonstrated that regulatory CD4+CD25+ CD45RO+ T cells are present in the peripheral blood of healthy adults and exert regulatory function similar to their rodent counterparts. It remains difficult to understand how the small fraction of these T cells that regulate via direct cell-to-cell contact and not via secretion of immunosuppressive cytokines could mediate strong immune suppression. Here we show that human CD4+CD25+ T cells induce long-lasting anergy and production of interleukin (IL)-10 in CD4+CD25− T cells. These anergized CD4+CD25− T cells then suppress proliferation of syngenic CD4+ T cells via IL-10 but independent of direct cell contact, similar to the so-called type 1 regulatory T (Tr1) cells. This ‘catalytic’ function of CD4+CD25+ T cells to induce Tr1-like cells helps to explain their central role for the maintenance of immune homeostasis.</jats:p>
収録刊行物
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- The Journal of Experimental Medicine
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The Journal of Experimental Medicine 196 (2), 247-253, 2002-07-15
Rockefeller University Press
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詳細情報 詳細情報について
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- CRID
- 1363951795189653120
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- NII論文ID
- 30017416825
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- ISSN
- 15409538
- 00221007
- http://id.crossref.org/issn/00221007
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- データソース種別
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- Crossref
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