Human Dendritic Cells Activated by TSLP and CD40L Induce Proallergic Cytotoxic T Cells
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- Michel Gilliet
- DNAX Research Institute, Palo Alto, CA 94304
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- Vassili Soumelis
- DNAX Research Institute, Palo Alto, CA 94304
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- Norihiko Watanabe
- DNAX Research Institute, Palo Alto, CA 94304
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- Shino Hanabuchi
- DNAX Research Institute, Palo Alto, CA 94304
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- Svetlana Antonenko
- DNAX Research Institute, Palo Alto, CA 94304
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- Rene de Waal-Malefyt
- DNAX Research Institute, Palo Alto, CA 94304
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- Yong-Jun Liu
- DNAX Research Institute, Palo Alto, CA 94304
抄録
<jats:p>Human thymic stromal lymphopoietin (TSLP) is a novel epithelial cell–derived cytokine, which induces dendritic cell (DC)-mediated CD4+ T cell responses with a proallergic phenotype. Although the participation of CD8+ T cells in allergic inflammation is well documented, their functional properties as well as the pathways leading to their generation remain poorly understood. Here, we show that TSLP-activated CD11c+ DCs potently activate and expand naive CD8+ T cells, and induce their differentiation into interleukin (IL)-5 and IL-13–producing effectors exhibiting poor cytolytic activity. Additional CD40L triggering of TSLP-activated DCs induced CD8+ T cells with potent cytolytic activity, producing large amounts of interferon (IFN)-γ, while retaining their capacity to produce IL-5 and IL-13. These data further support the role of TSLP as initial trigger of allergic T cell responses and suggest that CD40L-expressing cells may act in combination with TSLP to amplify and sustain pro-allergic responses and cause tissue damage by promoting the generation of IFN-γ–producing cytotoxic effectors.</jats:p>
収録刊行物
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- The Journal of Experimental Medicine
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The Journal of Experimental Medicine 197 (8), 1059-1063, 2003-04-21
Rockefeller University Press
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詳細情報 詳細情報について
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- CRID
- 1360299149409097856
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- NII論文ID
- 30017417064
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- ISSN
- 15409538
- 00221007
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