Differentiation of Effector/Memory Vδ2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites

DOI PDF 5 Citations
  • Francesco Dieli
    1Department of Biopathology, University of Palermo, 90134 Palermo, Italy
  • Fabrizio Poccia
    2Laboratory of Immunology, National Institute for Infectious Diseases “L. Spallanzani,” 00149 Rome, Italy
  • Martin Lipp
    3Max-Delbruch Center for Molecular Medicine, 13122 Berlin-Busch, Germany
  • Guido Sireci
    1Department of Biopathology, University of Palermo, 90134 Palermo, Italy
  • Nadia Caccamo
    1Department of Biopathology, University of Palermo, 90134 Palermo, Italy
  • Caterina Di Sano
    4Institute of Biomedicine and Molecular Immunology, National Research Council, 90134 Palermo, Italy
  • Alfredo Salerno
    1Department of Biopathology, University of Palermo, 90134 Palermo, Italy

Abstract

<jats:p>Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and mount both immediate effector functions and memory responses after microbial infection. However, how Vδ2 T cells mediate different facets of a memory response remains unknown. Here, we show that the expression of CD45RA and CD27 antigens defines four subsets of human Vδ2 T cells with distinctive compartmentalization routes. Naive CD45RA+CD27+ and memory CD45RA−CD27+ cells express lymph node homing receptors, abound in lymph nodes, and lack immediate effector functions. Conversely, memory CD45RA−CD27− and terminally differentiated CD45RA+CD27− cells, which express receptors for homing to inflamed tissues, are poorly represented in the lymph nodes while abounding at sites of inflammation, and display immediate effector functions. These observations and additional in vitro experiments indicate a lineage differentiation pattern for human Vδ2 T cells that generates naive cells circulating in lymph nodes, effector/memory cells patrolling the blood, and terminally differentiated effector cells residing in inflamed tissues.</jats:p>

Journal

Citations (5)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top