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- Hugh O. McDevitt
- From the National Institute for Medical Research, Mill Hill, London, England, and the Weizmann Institute of Science, Rehovoth, Israel
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- Michael Sela
- From the National Institute for Medical Research, Mill Hill, London, England, and the Weizmann Institute of Science, Rehovoth, Israel
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抄録
<jats:p>Immunization of CBA and C57 mice with a branched, multichain synthetic polypeptide, poly (tyr,glu)-poly DL-ala--poly lys, ((T,G)-A--L), in Freund's complete adjuvant results in a tenfold or more difference in the antigen-binding capacity of sera from the two strains, although they respond equally to bovine serum albumin. Immunization of CBA x C57 F1, F1 x CBA, and F1 x C57 mice reveals definite genetic control of the response to (T,G)-A--L, which appears to be due to a single major genetic factor, with perhaps one or more modifying factors. Immunization of CBA and C57 mice with (H,G)-A--L, a synthetic polypeptide in which histidine replaces tyrosine, gives the opposite result, CBA's respond and C57's do not. From this, it appears that the genetic control of the response to (T,G)-A--L is specific for the antigenic determinant. The implications of these results are discussed.</jats:p>
収録刊行物
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- The Journal of Experimental Medicine
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The Journal of Experimental Medicine 122 (3), 517-531, 1965-09-01
Rockefeller University Press
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詳細情報 詳細情報について
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- CRID
- 1361981471084853760
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- NII論文ID
- 30017423490
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- NII書誌ID
- AA00697559
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- ISSN
- 15409538
- 00221007
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