Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.

DOI PDF 被引用文献9件
  • E Maggi
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • M G Giudizi
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • R Biagiotti
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • F Annunziato
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • R Manetti
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • M P Piccinni
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • P Parronchi
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • S Sampognaro
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • L Giannarini
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • G Zuccati
    Division of Clinical Immunology and Allergy, University of Florence, Italy.
  • S Romagnani
    Division of Clinical Immunology and Allergy, University of Florence, Italy.

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<jats:p>We analyzed at clonal level the functional profile of circulating or skin-infiltrating T lymphocytes from two individuals infected with the human immunodeficiency virus type 1 (HIV-1), suffering from a Job's-like syndrome (eczematous dermatitis, recurrent skin and sinopulmonary infections, and hypergammaglobulinemia E) and showing virtually no circulating CD4+ T cells. Most of the CD3+ T cell clones generated from both patients were CD4- CD8+ TCR alpha beta +. The others were CD4- CD8- TCR alpha beta + which exhibited reduced mRNA expression for the CD8 molecule or no mRNA expression for either CD4 or CD8 molecules. The great majority of both CD4- CD8+ and CD4- CD8- did not produce interferon (IFN) gamma and exhibited reduced cytolytic activity. Rather, most of them produced large amounts of both interleukin (IL) 4 and IL-5 and provided B cell helper function for IgE synthesis. These data suggest that a switch of cytolytic CD8+ T cells showing a Th1-like cytokine secretion profile to cells that make Th2-type cytokines, exhibit reduced cytolytic potential, and provide B cell helper function can occur in the course of HIV-1 infection. These cells may contribute to the reduced defense against viral infections and intracellular parasites and account for the elevated IgE serum levels, eosinophilia, and the allergic-like clinical manifestations seen in a proportion of HIV-1-infected individuals.</jats:p>

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