Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

DOI PDF 被引用文献25件
  • J L Telford
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • P Ghiara
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • M Dell'Orco
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • M Comanducci
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • D Burroni
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • M Bugnoli
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • M F Tecce
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • S Censini
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • A Covacci
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.
  • Z Xiang
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy.

抄録

<jats:p>The gram negative, microaerophilic bacterium Helicobacter pylori colonizes the human gastric mucosa and establishes a chronic infection that is tightly associated with atrophic gastritis, peptic ulcer, and gastric carcinoma. Cloning of the H. pylori cytotoxin gene shows that the protein is synthesized as a 140-kD precursor that is processed to a 94-kD fully active toxin. Oral administration to mice of the purified 94-kD protein caused ulceration and gastric lesions that bear some similarities to the pathology observed in humans. The cloning of the cytotoxin gene and the development of a mouse model of human gastric disease will provide the basis for the understanding of H. pylori pathogenesis and the development of therapeutics and vaccines.</jats:p>

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