Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

DOI PDF 被引用文献31件
  • L A Casciola-Rosen
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
  • G Anhalt
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
  • A Rosen
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

この論文をさがす

抄録

<jats:p>Systemic lupus erythematosus is a multisystem autoimmune disease in which the autoantibody response targets a variety of autoantigens of diverse subcellular location. We show here that these autoantigens are clustered in two distinct populations of blebs at the surface of apoptotic cells. The population of smaller blebs contains fragmented endoplasmic reticulum (ER) and ribosomes, as well as the ribonucleoprotein, Ro. The larger blebs (apoptotic bodies) contain nucleosomal DNA, Ro, La, and the small nuclear ribonucleoproteins. These autoantigen clusters have in common their proximity to the ER and nuclear membranes, sites of increased generation of reactive oxygen species in apoptotic cells. Oxidative modification at these sites may be a mechanism that unites this diverse group of molecules together as autoantigens.</jats:p>

収録刊行物

被引用文献 (31)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ