Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways.
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- G Koopman
- Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
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- H K Parmentier
- Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
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- H J Schuurman
- Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
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- W Newman
- Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
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- C J Meijer
- Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
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- S T Pals
- Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
抄録
<jats:p>Presentation of antigen in the form of immune complexes to B lymphocytes by follicular dendritic cells (FDC) is considered to be a central step in the generation of memory B cells. During this process, which takes place in the microenvironment of the germinal center, B cells and FDC are in close physical contact. In the present study, we have explored the molecular basis of FDC-B cell interaction by using FDC and B cells derived from human tonsils. We found that FDC express high levels of the adhesion receptors intercellular adhesion molecule 1 (ICAM-1 [CD54]) and vascular cell adhesion molecule 1 (VCAM-1), while the B lymphocytes express lymphocyte function-associated antigen 1 (LFA-1 [CD11a/18]), very late antigen 4 (VLA-4 [CD49d], and CD44. Furthermore, we established that both the LFA-1/ICAM-1 and VLA-4/VCAM-1 adhesion pathways are involved in FDC-B lymphocyte binding, and therefore, these pathways might be essential in affinity selection of B cells and in the formation of B memory cells.</jats:p>
収録刊行物
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- The Journal of experimental medicine
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The Journal of experimental medicine 173 (6), 1297-1304, 1991-06-01
Rockefeller University Press
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詳細情報
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- CRID
- 1360855568720152704
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- NII論文ID
- 30017433205
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- ISSN
- 15409538
- 00221007
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