Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma
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- Michael I. Koukourakis
- 1Radiotherapy/Oncology and Departments of
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- Alexandra Giatromanolaki
- 2Pathology, Democritus University of Thrace, Alexandroupolis, Greece; and
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- Adrian L. Harris
- 3Molecular Oncology Laboratories, Cancer Research UK, Institute of Molecular Medicine, John Radcliffe Hospital, United Kingdom
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- Efthimios Sivridis
- 2Pathology, Democritus University of Thrace, Alexandroupolis, Greece; and
抄録
<jats:title>Abstract</jats:title> <jats:p>Understanding tumor metabolism is important for the development of anticancer therapies. Immunohistochemical evaluation of colorectal adenocarcinomas showed that cancer cells share common enzyme/transporter activities suggestive of an anaerobic metabolism [high lactate dehydrogenase 5 (LDH5)/hypoxia-inducible factor αs (HIFαs)] with high ability for glucose absorption and lactate extrusion [high glucose transporter 1 (GLUT1)/monocarboxylate transporter (MCT1)]. The tumor-associated fibroblasts expressed proteins involved in lactate absorption (high MCT1/MCT2), lactate oxidation (high LDH1 and low HIFαs/LDH5), and reduced glucose absorption (low GLUT1). The expression profile of the tumor-associated endothelium indicated aerobic metabolism (high LDH1 and low HIFαs/LDH5), high glucose absorption (high GLUT1), and resistance to lactate intake (lack of MCT1). It is suggested that the newly formed stroma and vasculature express complementary metabolic pathways, buffering and recycling products of anaerobic metabolism to sustain cancer cell survival. Tumors survive and grow because they are capable of organizing the regional fibroblasts and endothelial cells into a harmoniously collaborating metabolic domain. (Cancer Res 2006; 66(2): 632-7)</jats:p>
収録刊行物
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- Cancer Research
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Cancer Research 66 (2), 632-637, 2006-01-15
American Association for Cancer Research (AACR)
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詳細情報 詳細情報について
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- CRID
- 1363951795003521280
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- NII論文ID
- 30018587749
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- ISSN
- 15387445
- 00085472
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